Sustained response to infliximab in 2 patients with refractory relapsing polychondritis.

Successful treatment of relapsing polychondritis with infliximab.

Relapsing polychondritis (RP) is a rare and potentially fatal autoimmune disease in which an inappropriate immune response destroys the cartilage of the ears, larynx and nose. Many therapeutic approaches have been reported. We describe the results obtained with infliximab in a patient with RP unresponsive to conventional therapy. This therapy could be a new weapon to treat refractory RP.

Sustained response to infliximab in 2 patients with refractory relapsing

Limbic Encephalitis Associated with Relapsing Polychondritis Responded to Infliximab and Maintained Its Condition without Recurrence after Discontinuation: a Case Report and Review of the Literature

Central nervous system (CNS) manifestations are rare complications of relapsing polychondritis (RP). The majority of patients respond well to glucocorticoid therapy, but need to maintain it. Some patients are refractory to initial glucocorticoid therapy and to additional immunosuppressants, and end up with an outcome worse than at therapy initiation. The standardized therapeutic protocol for th...

Economic Evaluation of Infliximab for Treatment of Refractory Ulcerative Colitis in Iran: Cost-Effectiveness Analysis

The aim of this study is to assess cost-effectiveness of infliximab, compared with conventional treatments in patients with moderate to severe Ulcerative Colitis (UC) in Iran. We developed an analytical decision model with a 5-year-time horizon to follow up 1000 hypothetical patients, in order to estimate treatment costs and outcomes. Hypothetical patients, were individuals with moderate to sev...

Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab.

We are grateful to the many patients who contributed samples to these studies and to the National Ankylosing Spondylitis Society (UK) for additional financial support and help in patient recruitment. D.H. is funded by Arthritis Research UK (Grant 19356). B.P.W. and J.J.P. are supported by the National Institute for Health Research (NIHR) Oxford Comprehensive Biomedical Research Centre and the N...